Endocrine Abstracts

It has been well known the primary aldosteronism (PA) is the most common endocrine hypertension, and it is accounted approximately 10% of all hypertensive patients. It is always challenging for physicians which tests we should select for the confirmatory tests for the patients with aldosterone-renin retio (ARR) positive. We analyzed our 83 PA patients for the sensitivity of each confirmatory test.We screened those PA suspicious patients by ARR and we con...

Here, we investigated roles of p38 MAPK pathway in the regulation of FSH-induced steroidogenesis using co-culture of rat primary granulosa cells with oocytes. The p38 protein was readily phosphorylated in granulosa cells by treatment with activin and FSH. The activin effect on p38 phosphorylation was abolished by a selective ALK-4, -5, -7 inhibitor SB431542. SB431542 suppressed FSH-induced estradiol production, but had no effect on progesterone production with a marginal reduc...